LeSean McCoy RB PHI 24 Mins

McCoy suffered a left knee injury in the fourth quarter of Sunday's game against the Giants and is questionable to return, the Philadelphia Inquirer's Jeff McLane reports.

With only a few minutes remaining and no playoff appearance on tap for the Eagles, this may be it for McCoy in 2014. Darren Sproles and Chris Polk will handle the rushing duties with McCoy out.

Rashad Johnson DB ARI 37 Mins

Johnson (ankle) is listed as active Sunday in San Francisco, the Cardinals' official site reports.

Johnson will take on his normal spot in the starting lineup at free safety in his quest to add to a career season (89 tackles, four interception, two touchdowns, one sack, and one fumble recovery).

Larry Donnell TE NYG 44 Mins

Donnell suffered a right ankle injury in the second half of Sunday's game against the Eagles and will not return, ESPN.com's Dan Graziano reports.

Donnell attempted to play with a large wrap on his ankle, but he was noticeably slowed and eventually came out of the game. He finished with two catches for 26 yards.

Larry Foote LB ARI 45 Mins

Foote (knee) is inactive for Sunday's game in San Francisco, the Cardinals' official site reports.

Prior to the season finale, Foote logged all but one of Arizona's defensive snaps, which may have been the impetus for Sunday's absence with the postseason imminent. He'll yield his starting spot at one of the inside linebacker spots to undrafted rookie Glenn Carson.

Calais Campbell DL ARI 50 Mins

Campbell (hip) is listed as active Sunday in San Francisco, the Cardinals' official site reports.

After putting up zeroes in the box score last Sunday against the Seahawks, Campbell should bounce back against a 49ers offensive line that has given up 51 sacks of Colin Kaepernick this season.

Reggie Wayne WR IND 52 Mins

Wayne suffered a groin injury Sunday against the Titans, the Associated Press reports.

Prior to his exit from Sunday's game, Wayne caught two passes for 91 yards, with his injury occurring at the tail end of an 80-yard passing play.

Deone Bucannon DB ARI 55 Mins

Bucannon (knee) is active for Sunday's contest in San Francisco, the Cardinals' official site reports.

Even though he's split snaps with Tony Jefferson at strong safety this season, Bucannon has been steadfast as a rookie, racking up 76 tackles (63 solo), two sacks, one forced fumble, and one fumble recovery.

Jaron Brown WR ARI 1 Hr

Brown (toe) is listed as active Sunday at San Francisco, the Cardinals' official site reports.

In the two contests with Ryan Lindley under center, Brown has reeled in just one of two passes for six yards, which isn't exactly helpful in the world of fantasy.

Chris Culliver DB SF 1 Hr

Culliver (knee) is listed as active Sunday against the Cardinals.

Culliver will slot into his typical spot at cornerback, with a new running mate in Dontae Johnson looking to profit from the Cardinals' mistake-prone quarterback Ryan Lindley.

Perrish Cox DB SF 1 Hr

Cox (shoulder) is inactive for Sunday's game against the Cardinals.

Cox's ledger includes 53 tackles (49 solo), which he's supplemented with five interceptions and two fumble recoveries in 15 contests. However, his first DNP of the season will place Dontae Johnson in the starting lineup at cornerback opposite Chris Culliver (knee).