Mario Manningham WR NYG 7 Months

49ers placed WR Mario Manningham (knee) on injured reserve, ending his season.

Look for rookie Quinton Patton to get a long look for San Francisco's third receiver role in Week 17 against Arizona. Manningham tore multiple knee ligaments late in the 2012 season and recently suffered a setback. His 2013 season ends with nine receptions for 85 yards among six appearances, starting three. Manningham is an impending free agent and long shot to return to the 49ers in 2014. There is some fear his career could be in jeopardy.

Mario Manningham WR NYG 7 Months

49ers coach Jim Harbaugh conceded Friday that Mario Manningham (knee) is unlikely to play in Week 17 against the Cardinals.

Manningham was downgraded to "out" in Thursday's practice after participating on a limited basis Wednesday. He also missed Week 16, and appears to be dealing with a setback after tearing multiple knee ligaments late in 2012. The 49ers will move forward with Michael Crabtree bookending Anquan Boldin.

Mario Manningham WR NYG 7 Months

Mario Manningham (knee) was downgraded to "out" in Thursday's practice.

Manningham was spotted trying to give things a go at the start of practice, but quickly pulled himself out. It appears he'll miss his second straight game Sunday. Manningham should be considered questionable for the playoffs.

Mario Manningham WR NYG 7 Months

Mario Manningham (knee) was limited in 49ers practice Wednesday.

Manningham was something of a surprise scratch in Monday night's loss to Atlanta. When healthy, he has been San Francisco's third receiver this season.

Mario Manningham WR NYG 7 Months

Mario Manningham (knee, illness) is inactive for Monday night's Week 16 game against the Falcons.

Manningham was listed as questionable and will be replaced by more talented rookie Quinton Patton as the No. 3 receiver. Also inactive for the 49ers are WR Jon Baldwin, TE Derek Carrier, LB Nick Moody, DL Quinton Dial, OL Joe Looney, and OL Ryan Seymour. LG Mike Iupati (knee) is back after missing four games.

Mario Manningham WR NYG 7 Months

Mario Manningham (knee, illness) is listed as questionable for Week 16.

Manningham has played the last six weeks despite being listed as questionable. He should be all systems go as San Francisco's No. 3 receiver for Monday night's game against the Falcons.

Mario Manningham WR NYG 7 Months

Mario Manningham (knee, illness) returned to 49ers practice Friday.

Look for Manningham to be probable on Saturday's final injury report. The Niners host the Falcons on Monday Night Football in fantasy finals week.

Mario Manningham WR NYG 7 Months

Mario Manningham (illness, knee) was held out of 49ers practice Thursday.

Manningham has missed a fair amount of practice time since returning in Week 10, but has yet to miss a game. He should be active as San Francisco's No. 3 receiver for Monday night's game against the Falcons. He's well off the fantasy radar.

Mario Manningham WR NYG 7 Months

Mario Manningham (knee) is active for Sunday's game against the Bucs.

Michael Crabtree's return has rendered Manningham completely useless in fantasy whether he's healthy or not. The ex-Giant has zero catches over the last two weeks.

Mario Manningham WR NYG 7 Months

Mario Manningham (knee) is listed as questionable for Week 15 versus the Bucs.

Manningham is battling general soreness after ripping his knee up last season. He hasn't caught a ball the past two weeks and isn't a fantasy option.